ATM in senescence
نویسندگان
چکیده
منابع مشابه
ATM in senescence
Senescence is a state of stable cell growth arrest that can be triggered by multiple stressors, including oncogene activation [1]. In normal diploid mammalian cells, activation of oncogenes such as oncogenic RAS or BRAF decreases dNTP levels, which leads to replication stress and ultimately senescence [2]. In this context, oncogene-induced senescence (OIS) is considered to be an important tumor...
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Recent studies in human fibroblasts have provided a new general paradigm of tumor suppression according to which oncogenic signaling produces DNA damage and this, in turn, results in ATM/p53-dependent cellular senescence. Here, we have tested this model in a variety of murine experimental systems. Overexpression of oncogenic Ras in murine fibroblasts efficiently induced senescence but this occu...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2015
ISSN: 1949-2553
DOI: 10.18632/oncotarget.4411